If there's a seminal discovery in oncology in the last 20 years, it's that idea that cancer genes are often mutated versions of normal genes.
I am a scientist and I am a physician. So I write papers. Siddhartha Mukhe
Cancer was not disorganized chromosomal chaos. It was organized chromosomal chaos
Most days, I go home and I feel rejuvenated. I feel ebullient.
Good physicians are rarely dispassionate. They agonize and self-doubt over patients. Siddhartha Mukherje
It remains an astonishing, disturbing fact that in America - a nation where nearly every new drug is subjected to rigorous scrutiny as a potential carcinogen, and even the bare hint of a substance's link to cancer ignites a firestorm of public hysteria and media anxiety - one of the most potent and
I think the cardinal rule of learning to write is learning to read first. I learned to write by learning to read.
Cancer has enormous diversity and behaves differently: it's highly mutable, the evolutionary principles are very complicated and often its capacity to be constantly mystifying comes as a big challenge.
A positive attitude does not cure cancer, any more than a negative one causes it.
Could your medicine be a cell, not a pill? Could your medicine be an organ that's created outside the body? Could your medicine be an environment?
I am a scientist and I am a physician. So I write papers.
It is hard to look at the tumor and not come away with the feeling that one has encountered a powerful monster in its infancy
In Paris, friend of Bequerelâ€™s, a young physicist-chemist couple named Pierre and Marie Curie, began to scour the natural world for even more powerful chemical sources of X-rays. Pierre and Marie (then Maria Sklodowska, a penniless Polish immigrant living in a garret in Paris) had met at the Sorbo
I left Delhi in 1989 and remember very little of how life used to be then. Increasingly, in my recent visits to Delhi, I've started to realize that the city has become intellectually very lively. It makes me want to discover the city over and over again.
History repeats, but science reverberates.
Down to their innate molecular core, cancer cells are hyperactive, survival-endowed, scrappy, fecund, inventive copies of ourselves.
There is a duality in recognising what an incredible disease it is - in terms of its origin, that it emerges out of a normal cell. It's a reminder of what a wonderful thing a normal cell is. In a very cold, scientific sense, I think a cancer cell is a kind of biological marvel.
What does it mean to be an oncologist? It means that you get to sit in at a moment of another person's life that is so hyper-acute, and not just because they're medically ill. It's also a moment of hope and expectation and concern.
There's a phrase in Shakespeare: he refers to it as the 'hidden imposthume', and this idea of a hidden swelling is seminal to cancer. But even in more contemporary writing it's called 'the big C'.
Writing anything as an expert is really poisonous to the writing process, because you lose the quality of discovery.
One swallow is a coincidence, but two swallows make summer.
Most discoveries even today are a combination of serendipity and of searching.
In 2005, a man diagnosed with multiple myeloma asked me if he would be alive to watch his daughter graduate from high school in a few months. In 2009, bound to a wheelchair, he watched his daughter graduate from college. The wheelchair had nothing to do with his cancer. The man had fallen down while
I think when we use 'stress', we are often using a kind of dummy word to try to fit many different things into one big category.
I wanted to explore cancer not just biologically, but metaphorically. The idea that tuberculosis in the 19th century possessed the same kind of frightening and decaying quality was very interesting to me, and it seemed that one could explore the idea that every age defined its own illness.
I began wondering, can one really write a biography of an illness? But I found myself thinking of cancer as this character that has lived for 4,000 years, and I wanted to know what was its birth, what is its mind, its personality, its psyche?
Sandeep Jauharâ€™s Doctored is a passionate and necessary book that asks difficult questions about the future of medicine. The narrative is gripping, and the writing is marvelous. But it was the gravity of the problemâ€”so movingly toldâ€”that grabbed and kept my attention throughout this remarkable
Good physicians are rarely dispassionate. They agonize and self-doubt over patients.
There's a rising cancer trend and, as I said, one of the major contributors is the overall ageing of the population - we aren't dying of other things, so we're dying of cancer.
There is a very moving and ancient connection between cancer and depression.